Staff Directory Details

Dr. Jenean O'Brien

Dr. Jenean O'Brien
Dr. Jenean O'Brien
Jenean O'Brien Dr Jenean O'Brien
Assistant Professor, Biology
office. BARS 205A
University of Wisconsin-Superior

Education

PhD in Cancer Biology from the University of Colorado Denver, 2010

BA in Biology from the College of St. Scholastica, 2005

Courses

BIOL 123 – Concepts in Biology

BIOL 330 – Genetics

BIOL 335 – Microbes and Defense

BIOL 399 – Cancer Biology

BIOL 440 – Cell Biology

Role as Faculty

My goal is to create a supportive environment in which you can take control of your learning and career preparation.

Research Interests

We are interested in how tumor cell genes often direct similar functions to those they promote in normal cells during development. This can provide insight into potential ways to treat cancer cells to stop these tumor-promoting actions.

Specifically, we focus on the Eya protein family of transcriptional co-factors, asking if what they do in rhabdomyosarcoma, a pediatric muscle cancer, is similar to what Eya proteins do during muscle development in an embryo. We are also interested in potentially investigating if the Eya proteins have roles in the vertebrate immune system as well. We use zebrafish as our model organism.

Student Opportunities

My research program is focused on providing students with experience in a molecular biology laboratory. Students get a chance to apply concepts and techniques learned in our courses through performing hypothesis-driven research. This exposure is also a great way to learn whether this would be something you would like to do in your future career.

Ways to become involved include:

  • Take BIOL 330 – Genetics and BIOL 440 – Cell Biology to learn how to perform research techniques with zebrafish.
  • Work in the zebrafish lab – feeding, checking water chemistry and maintaining transgenic models.
  • Do an independent research project (BIOL 491) for a semester – or more.
  • Line up an internship with a local clinician (BIOL 496) for a semester.
  • Apply for a Summer Undergraduate Research Fellowship (SURF).

Recent Scholarly Activity

UW-Superior Innovation Proposal, “Strengthening the Pre-Health Focus”                      

January 2016-2017

Association for Biology Laboratory Education - Roberta Williams Laboratory Teaching Initiative Grant, “Training data-wise science consumers through formatting lab reports into data figures”

July 2015-June 2016

Publications

  1. Powell, D.R., Williams, J.S., Hernandez-Lagunas, L., Salcedo, E., O’Brien, J.H, Artinger, K.B, Cdon promotes neural crest migration by regulating N-cadherin localization. Developmental Biology, 407(2): 289-99, 2015. PMID 26256768
  1. O'Brien, J.H., Hernandez-Lagunas, L., Artinger, K.B., Ford, H.L. MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1, Journal of Cell Science, 127(10): 2291-301, 2014. PMID 24634509
  1. Powell, D.R., O’Brien, J.H. (co-first author), Ford, H.L., Artinger, K.B. Chapter 16: Neural crest cells and cancer: insights into tumor progression in Neural Crest Cells: evolution, development and disease, P.A. Trainor, (Ed.), San Diego, CA: Elsevier, 2014.
  1. Harvell, D.M., Kim, J., O’Brien, J., Tan, A.C., Schedin, P., Borges, V.F., Jacobsen, B.M., Horwitz., K.B. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone hormones, Hormones and Cancer, 4(3):140-53, 2013. PMID 23479404
  1. O’Brien, J., Vanderlinden, L.A., Schedin, P., and Hansen, K.C. Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis, Journal of Proteome Research, 11(10): 4895-905, 2012. PMID 22897585
  1. O’Brien, J., Martinson, H., Durand-Rougely, C., and Schedin, P. Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution, Development, 139(2): 269-75, 2012. PMID 22129827
  1. O’Brien, J., Hansen, K., Barkan, D., Green, J., and Schedin, P. Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland, International Journal of Developmental Biology, 55(7-8-9): 745-755, 2011.  PMID 22161831
  1. Lyons, T.R., O’Brien, J. (co-first author), Borges, V., Conklin, M.W., Keely, P.J., Elicieri, K.W., Marusyk, A., Tan, A.C., and Schedin, P. Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2, Nature Medicine, 17(9): 1109-15, 2011. PMID 21822285
  1. O’Brien, J., Fornetti, J., Schedin P. Isolation of mammary-specific extracellular matrix to assess acute cell-ECM interactions in 3D culture, Journal of Mammary Gland Biology and Neoplasia, 15(3): 353-64, 2010. PMID 20680416
  1. O’Brien, J., Lyons, T. (co-first author), Monks, J., Lucia, M.S., Wilson, R.S., Hines, L., Man, Y.G., Borges, V., and Schedin, P. Alternatively activated macrophages and collagen remodeling characterize the post-partum involuting mammary gland across species. American Journal of Pathology, 176(3): 1241-55, 2010. PMID 20110414

 

  1. O’Brien, J. and Schedin, P. Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer? Journal of Mammary Gland Biology and Neoplasia, 14(2): 145-57, 2009. PMID 19350209

 

  1. Hansen, K.C., Kiemele, L., Maller, O., O’Brien, J., Shankar, A., Fornetti, J., Schedin, P. An in-solution ultrasonication assisted digestion method for improved extracellular matrix proteome coverage. Molecular and Cellular Proteomics, 8(7):1648-57, 2009. PMID 19351662

 

  1. Schedin, P., O’Brien, J., Rudolph, M., Stein, T., and V. Borges, The microenvironment of the involuting mammary gland mediates mammary cancer progression. Journal of Mammary Gland Biology and Neoplasia, 12(1): 71-82, 2007. PMID 17318269
Jenean teaches in the program:
Jenean is involved with these Committees:
Jenean is a member of:

UW-Superior Schedule of Classes for O'Brien, Jenean H
Fall Semester 2018

For up to date information on all schedules, please refer to the class search page in the E-Hive portal.

Note: the Class Schedule information below reflects data as of April 21, 2018 11:45 AM.

Class Section Identifier Key

Fall Semester 2018
Class Nbr.Catalog Nbr.Course Title/Course TopicsClass Sect.CreditsBldg.RoomDaysTimeSeats Open
BIOL - Biology
1603BIOL 440Cell Biology
View Books for this Class
09/05/2018 - 12/14/2018
All Natural Science classes will be assessed a program fee of $12 per credit
101 4.00  SWEN 1055 MW 3:00PM- 4:15PM 18 of 40 open
Wait List:
10 of 10
  
09/05/2018 - 12/14/2018
All Natural Science classes will be assessed a program fee of $12 per credit
1605BIOL 440Cell Biology Lab
View Books for this Class
09/05/2018 - 12/14/2018
501 0.00  BARS 0102 Th 10:00AM- 11:50AM 7 of 20 open
Wait List:
5 of 5
  
09/05/2018 - 12/14/2018
1606BIOL 440Cell Biology Lab
View Books for this Class
09/05/2018 - 12/14/2018
502 0.00  BARS 0102 Th 1:00PM- 2:50PM 11 of 20 open
Wait List:
5 of 5
  
09/05/2018 - 12/14/2018
1624BIOL 491Research in Biology
View Books for this Class
09/05/2018 - 12/14/2018
Instructor Consent Required
All Natural Science classes will be assessed a program fee of $12 per credit
004 1.00 - 4.00     ARR 5 of 5 open
  
09/05/2018 - 12/14/2018
Instructor Consent Required
All Natural Science classes will be assessed a program fee of $12 per credit
1635BIOL 496Internship
View Books for this Class
09/05/2018 - 12/14/2018
Instructor Consent Required
All Natural Science classes will be assessed a program fee of $12 per credit
004 1.00 - 4.00     ARR 5 of 5 open
  
09/05/2018 - 12/14/2018
Instructor Consent Required
All Natural Science classes will be assessed a program fee of $12 per credit